Routine Analysis laboratories play a very important role in protecting integrity across a broad selection of sectors, from food and drink to forensic and pharmaceutical. With product safety and trustworthy decision-making at stake, these labs must balance productivity with the greatest standards of analytical precision. Yet, for labs operating at or close to capacity, or intending to grow their market share, scaling-up workflows without compromising on quality could be challenging. Liquid Chromatography LC technology, such as high performance liquid chromatography HPLC and ultra-high performance liquid chromatography UHPLC platforms, support a large proportion of regular analysis workflows. But these systems can be a significant source of inefficiency and function to restrict operational productivity. Specifically, issues with the adaptability and resilience of aging LC gear can be quite disruptive to workflows, making process transfer complex and increasing the demand for time-consuming manual actions.
Inadequate platform flexibility and robustness may also leave processes vulnerable to human error, resulting in the need for extra efforts to record out of specification results. This report considers common productivity bottlenecks in regular analysis labs, and explores how contemporary hplc testing technologies and laboratory informatics applications are helping companies overcome them. Routine Investigation labs may face several possible productivity challenges with respect to their LC workflows. Among the most frequent sources of inefficiency is the practice of transferring LC methods involving devices, where unexpected complications and delays can divert time away from analysing and have a significant effect on productivity. This is true not only when shifting methods between laboratories, like from analytic development to quality control QC configurations, or when outsourcing to contract labs, but also when scaling-up methods across multiple tools in the same lab or shifting workflows from legacy to new systems.
The ease and Speed of method transfer frequently depends upon many factors, including the robustness of the technique to be transferred, in addition to the instrumental deviations of the systems involved. Here, the technical qualities of the platform, such as gradient delay volume, pump mixing style, hydrodynamic behaviour, selection of column and eluent thermostatic possibilities, can all affect crucial performance results, such as summit retention or resolution times. The complexity of procedure transfer can also be determined in large part by the demands of the analytical result and defined limits of acceptable deviation from the initial system. Ideally, strategy transfer should happen with no method alterations to avoid spending considerable amounts of resources and time re-validating techniques.
